Repetitive transcranial magnetic stimulation combined with antidepressant medication in treatment of first-episode patients with major depression / 浙江大学学报·医学版

<p><b>OBJECTIVE</b>To assess the early therapeutic and cognitive effect of repetitive transcranial magnetic stimulation (rTMS) combined with antidepressant medication in treatment of first-episode patients with major depression.</p><p><b>METHODS</b>Sixty first-episode depressed inpatients aged 18-45 y, who met the DSM-IV clinical criteria for major depressive episode were randomly assigned to citalopram treatment (20 mg/d) in combination with a two-week period of either rTMS (study group)or sham procedure (control group) on left dorsal-lateral prefrontal cortex (10 Hz, 90% motor threshold). The Hamilton Depression Rating Scale (HAMD) was used to assess the severity of depression. The Wisconsin Card Sorting Test (WCST) and Continuous Performance Test (CPT) were used to assess cognitive function of depression.</p><p><b>RESULT</b>The response rate was significantly greater in the study group compared to the control group after treatment (57% compared with 29%,P<0.05). The HAMD scores significantly declined after treatment in two groups, and the study group showed lower scores compared to the control group after 2 weeks (P<0.01). Neuropsychological assessments showed that there was no significant difference between the two groups except for the significant improvement in the categories on WCST in study group compared to the baseline (P<0.05) and the control group (P<0.05)after 2 weeks treatment. No serious event occurred in the patients during the rTMS study.</p><p><b>CONCLUSION</b>10 Hz rTMS enhances early effects of citalopram and improves cognitive function in first-episode major depressive patients.</p>

A survey of mental health among transferred injured survivors in Wenchuan earthquake in Sichuan / 中华预防医学杂志

<p><b>OBJECTIVE</b>To assess the depression and anxious status among transferred injured survivors in Wenchuan earthquake in Sichuan province.</p><p><b>METHODS</b>A total of 43 transferred injured survivors were investigated by questionnaire exploring their trauma symptoms and mental health status.</p><p><b>RESULTS</b>High rates of trauma symptoms were remarkably observed in these survivors. Of all the respondents, 60% had some emotional symptoms and sleeping difficulties. About one third of respondents experienced recurrent and intrusive distressing recollection of event, 16 (37.21%) experienced nightmare, 15 (34.88%) had flashback and 7 (16.28%) of them tried to avoid relative stress.</p><p><b>CONCLUSION</b>Many mental symptoms were observed in transferred injured survivors. The two major factors of mental stress were emotional symptoms and re-experience of the disaster.</p>